Dose conversion from oral hydrocodone to once-daily Hysingla ER chronic pain therapy
Straightforward conversion from other hydrocodone formulations
To transition patients to Hysingla ER from any hydrocodone formulation: administer the patient's total daily oral hydrocodone dose as Hysingla ER once daily
The starting dose of Hysingla ER should be equivalent to the total daily dose of IR hydrocodone
- Patients receiving other oral hydrocodone-containing formulations can be transitioned to Hysingla ER by administering the patient's total daily oral hydrocodone dose as Hysingla ER once daily
- Discontinue all other around-the-clock opioid drugs when Hysingla ER therapy is initiated
- The starting dose of Hysingla ER may or may not be the dose that achieves an appropriate balance of analgesia and tolerability
- Achieving adequate analgesia may require titration in increments of 10 to 20 mg every 3 to 5 days or the use of supplemental IR analgesics for patients who experience breakthrough pain. Consider reducing the dosage of Hysingla ER if unacceptable adverse reactions are observed
1-to-1 IR hydrocodone to ER hydrocodone conversion example
Monitor patients closely for respiratory depression, especially within the first 24–72 hours of initiating therapy and following dosage increases with Hysingla ER and adjust the dosage accordingly.
To convert from a different opioid to Hysingla ER, please see section 2.2 of the Hysingla ER Full Prescribing Information, or visit HysinglaER.com.
Examples of appropriate starting doses for Hysingla ER
Vicodin® has 300 mg APAP. Norco® and Lortab® have 325 mg APAP.
Discontinue all other around-the-clock opioid drugs when Hysingla ER therapy is initiated.
