Titration and maintenance of Hysingla ER for chronic pain therapy

Individually titrate to a dose that provides adequate analgesia and minimizes adverse reactions

Titration can occur as frequently as once every 3 to 5 days as needed, as steady-state plasma hydrocodone concentrations are achieved by Day 3 of once-daily dosing.

Managing your patient's journey with Hysingla ER

Once treatment is established, remain mindful of your patient's evolving needs

  • If the level of pain increases after dose stabilization, attempt to identify the source of increased pain before increasing the Hysingla ER dosage
  • Supplemental IR analgesics can be used for breakthrough pain, should it occur
  • If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions
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